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PMID: 23449627 Free PMC article.Reference linking enables researchers to follow a link from the reference list to other full-text documents, helping them to make connections and discover new things. For permissions, please e-mail: DL, Berry DJ, Timpson NJ, Ang W, Thiering E, Byrne EM, Taal HR, Huikari V, Bradfield JP, Kerkhof M, Groen-Blokhuis MM, Kreiner-Møller E, Marinelli M, Holst C, Leinonen JT, Perry JR, Surakka I, Pietiläinen O, Kettunen J, Anttila V, Kaakinen M, Sovio U, Pouta A, Das S, Lagou V, Power C, Prokopenko I, Evans DM, Kemp JP, St Pourcain B, Ring S, Palotie A, Kajantie E, Osmond C, Lehtimäki T, Viikari JS, Kähönen M, Warrington NM, Lye SJ, Palmer LJ, Tiesler CM, Flexeder C, Montgomery GW, Medland SE, Hofman A, Hakonarson H, Guxens M, Bartels M, Salomaa V ReproGen Consortium Murabito JM, Kaprio J, Sørensen TI, Ballester F, Bisgaard H, Boomsma DI, Koppelman GH, Grant SF, Jaddoe VW, Martin NG, Heinrich J, Pennell CE, Raitakari OT, Eriksson JG, Smith GD, Hyppönen E, Järvelin MR, McCarthy MI, Ripatti S, Widén E Early Growth Genetics (EGG) Consortium. Published by Oxford University Press on behalf of the Endocrine Society. The menarche-related loci may contribute to early onset hypertension through endocrinological pathways.Īge at menarche cardiometabolic diseases molecular pathways shared genes. Our study highlights the usefulness of cross-trait analyses for identifying shared etiology between age at menarche and cardiometabolic traits, especially early onset hypertension.
Moreover, the TPLS provided evidence regarding a twofold higher risk of early onset hypertension that occurred in girls with central precocious puberty. These loci were confirmed through demonstration of significant changes in the methylation or expression levels of neighboring genes. Among the novel genes discovered, SEC16B, CSK, CYP1A1, FTO, and USB1 are within a protein interaction network with known cardiometabolic genes, including traits for obesity and hypertension. We discovered 27 novel loci, with an overlap between age at menarche and cardiometabolic traits, including body fat and blood pressure. To support the novel hypertension link, we used the Taiwan Puberty Longitudinal Study (TPLS) to investigate the influence of precocious puberty on childhood cardiometabolic traits. Using the conjunction false discovery rate method, this study analyzed genome-wide association study data from the menarche-cardiometabolic traits among 59,655 female of Taiwanese ancestry and systemically investigated pleiotropy between age at menarche and cardiometabolic traits. (1) To identify new shared genetic variants and their pathways for age at menarche and cardiometabolic traits and (2) to investigate the influence of central precocious puberty on childhood cardiometabolic traits. 13 Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan.Įxtremely early age at menarche, also called precocious puberty, has been associated with various cardiometabolic traits, but their shared heritability remains unclear.12 School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.11 Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.10 Cardiovascular Research Center, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
9 Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.8 Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.7 Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.6 Department of Computer Science and Engineering, Yuan Ze University, Taoyuan, Taiwan.5 Department of Mathematics, National Taiwan University Hospital, Taipei, Taiwan.4 Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.3 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.2 Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.1 Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
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